The Foreign Pharmacy Graduate Equivalency Examination® (FPGEE ®) is an exam that is required as a part of the FPGEC program. The FPGEE ® is offered twice a year throughout the continental United States. Everyone who is eligible during the FPGEC application process can take the exam. FPGEE ® Exam Distribution FPGEE ® exam consists of 250 questions. These questions are divided into four content areas. Basic biomedical sciences – 21%  Pharmaceutical Sciences – 29%  Social, behavioral, administrative pharmacy sciences – 15%  Clinical sciences – 35% Syllabus of FPGEE ® For those who are reading this article, I must recommend you to save this post for future purpose. Note all the points mentioned below which will help you in preparing for FPGEE ® Basic Biomedical Sciences – 21% A. Anatomy & Physiology 1. Structure and function of major body systems; integumentary, muscular-skeletal, cardiovascular, lymphatic, respiratory, digestive, nervous, endocrine, urinary, reproductive and body fluid and electrolytes 2. Molecular aspects of cell biology 3. Cell physiology and cellular structure and organization B. Pathology/Pathophysiology 1. Basic principles and mechanisms of disease including i. Inflammation and repair ii. Degeneration iii. Disturbances and hemodynamics iv. Developmental defects v. Neoplasia 2. Pathophysiology of disease states amenable to pharmacist intervention C. Microbiology 1. General principles of microbial concepts 2. Principles of infectious disease 3. Host-parasite relationships 4. Pathogenic micro-organisms of man 5. Inflammatory responses to infectious agents 6. Clinical aspects of infection D. Immunology 1. Human immunity and immune responses 2. Principles of antigen-antibody relationships 3. Molecular biology of immune responses 4. The Genetic basis for antibody synthesis, development, function, and immunopathology E. Biochemistry/Biotechnology 1. Chemistry of biomacromolecules (proteins, lipids, carbohydrates, and DNA) 2. Enzymology and co-enzymes and kinetics 3. Metabolic pathways to energy utilization 4. Nucleic acid metabolism including DNA replication and repair, RNA and protein synthesis 5. Recombinant DNA technology F. Molecular Biology/Genetics 1. Cell structure and components 2. Ion channels and receptor physiology 3. Mitosis and meiosis 4. Chromosomes and DNA 5. Gene transcription and translation processes 6. Recombinant DNA technology G. Biostatistics 1. Understanding commonly used statistical tests and their basis 2. Management of data sets 3. Evaluation of statistical results 4. Understanding of statistical versus clinical significance Pharmaceutical Sciences – 29% A. Medicinal Chemistry 1. Physio-chemical properties of drug molecules in relation to drug absorption, distribution, metabolism, and excretion (ADME) 2. Chemical basis and pharmacology and therapeutics 3. Fundamental pharmacophores for drugs used to treat disease 4. Structure-activity relationships in relation to drug-target interactions 5. Chemical pathways of drug metabolism 6. Application making drug therapy decisions B. Pharmacology 1. Mechanism of action of drugs of various categories 2. Role of pharmacology in drug choice and the treatment of disease 3. Pharmacodynamics of drug action and absorption, distribution, metabolism, and elimination 4. Adverse effects and side-effects of drugs 5. Drug-target interactions 6. Drug-drug, drug-food, drug-lab test interactions 7. Drug discovery and development C. Pharmacognosy and Alternative and Complementary Treatments 1. Concepts of crude drugs, semi-purified, and purified natural products 2. Variability of occurrence of pharmacologically active substances in plants and impact on regulatory aspects of herbal products 3. Overview of classes of pharmacologically active natural products 4. Dietary supplements (vitamins, minerals, and herbals) 5. Alternative medical treatments 6. Evaluation of alternative and complementary medicine purity, bioavailability, safety, and efficacy 7. Herbal-drug interactions 8. Dietary Health Supplement and Education Act and impact on the regulation of dietary supplements and herbal products D. Toxicology 1. Mechanism of toxicity and toxicokinetics 2. Acute and chronic toxic effect of xenobiotics on the body including drug or chemical overdose and toxic signs of drugs of abuse 3. Interpretation of drug screens 4. Antidotes and approaches to toxic exposures 5. Functions of poison control centers 6. Bioterrorism and disaster preparedness and management E. Bioanalysis/Clinical Chemistry 1. Fundamentals of laboratory medicine and its importance to screening, diagnosis, and evaluation of patients 2. Clinical data relevant to disease state management F. Pharmaceutics/Biopharmaceutics 1. Physical-chemical principles of dosage forms 2. Biological principles of dosage forms 3. Principles of drug delivery via dosage forms (eg, liquid, solid, semi-solid, controlled release, patches, and implants) 4. Principles of dosage form stability and drug degradation in dosage forms 5. Materials and methods used in the preparation and use of drug forms G. Pharmacokinetics/Clinical Pharmacokinetics 1. Basic principles of in vivo drug kinetics (linear and nonlinear) 2. Principles of bioavailability/bioequivalence 3. Physiologic determinates of drug onset and duration 4. Drug, disease, and dietary influences on absorption, distribution, metabolism, and excretion 5. Clinical pharmacokinetics of commonly used and low-therapeutic-index drugs 6. The pharmacokinetic-pharmacodynamic interface H. Pharmacogenomics/Genetics 1. The Genetic basis for disease and drug action 2. The Genetic basis for alteration and drug metabolism 3. Genome and proteomic principles in relation to disease and drug development 4. The Genetic basis for individualizing drug doses I. Extemporaneous Compounding/Parenteral/Enteral 1. United States Pharmacopeia (USP) guidance on compounding and Food and Drug Administration (FDA) Compliance Policy Guidelines 2. Techniques and principles used to prepare and dispense individual extemporaneous prescriptions including the dating of compounded dosage forms 3. Liquid (parenteral, enteral), solid, semi-solid, and topical preparations 4. Dosage form preparation calculations 5. Sterile admixture techniques a. USP Chapter 797 b. Stability and sterility testing and dating c. Clean room requirements d. Infusion devices and catheters Social/Behavioral/Administrative Pharmacy Sciences – 15% A. Health Care Delivery Systems 1. Introduction to United States, state, and local health care delivery systems and their interfaces 2. Social, political, and economic factors of the US health care delivery system 3. Principles that influence the distribution of pharmaceutical products and services 4. Role of public and private insurers, pharmaceutical industry, and managed care on health care delivery in the United States 5. Medicare and Medicaid 6. Indigent care programs 7. Incidence of and problems associated with drug overuse, underuse, and misuse in the US health care system B. Economics/Pharmacoeconomics 1. Economic principles in relation to pharmacoeconomic analysis 2. Concepts of pharmacoeconomics in relation to patient care 3. Applications of economic theories and health-related quality-of-life concepts to improve allocation of