You are currently viewing Common Antidote & Drug-Related Side Effects

Common Antidote & Drug-Related Side Effects

Antidote

An antidote is a drug, chelating substance, or a chemical that counteracts (neutralizes) the effects of another drug or a poison.

There are dozens of different antidotes; however, some may only counteract one particular drug, whereas others (such as charcoal) may help reduce the toxicity of numerous drugs. Most antidotes are not 100% effective, and fatalities may still occur even when an antidote has been given. Some examples of antidotes include:

ToxicityAntidote
ArsenicDimercaprol
BenzodiazepinesFlumazenil
AcetaminophenN-acetylcysteine
HeparinProtamine Sulfate
WarfarinVitamin K or Fresh-frozen plasma
Tissue Plasminogen ActivatorAminocaproic acid
MethotrexateLeucovarin (Folinic acid)
Sodium NitroprussideSodium Thiosulfate
β-blockersGlucagon
Carbon Monoxide100% Oxygen
OpioidNaloxone, Naltrexone
MethanolEthanol
OrganophosphatesAtropine, PAM
IronDesferoxamine
CyclophosphamideMesna
LeadD-penicillamine
Common Antidotes of Poisoning

Drug Related Side Effects

Side effects, also known as adverse events, are unwanted or unexpected events or reactions to a drug. Side effects can vary from minor problems like a runny nose to life-threatening events, such as an increased risk of a heart attack.

Several things can affect who does and does not have a side effect when taking a drug – age, gender, allergies, how the body absorbs the drug, other drugs, vitamins and dietary supplements that you may be taking. Common side effects include upset stomach, dry mouth, and drowsiness.

A side effect is considered serious if the result is: death; life-threatening; hospitalization; disability or permanent damage; or exposure prior to conception or during pregnancy caused birth defect.

Side effects can happen when you

  • start taking a new drug, dietary supplement, or vitamin/mineral
  • stop taking a drug that you’ve been on for a while, or
  • when you increase or decrease the amount of a drug that you take.
Side EffectCausative Drugs
Pulmonary Fibrosis
Bleomycin
Amiodarone
Busulfan
Pseudomembranous ColitisClindamycin
Ampicillin
Amoxicillin
TendonitisFluoroquinolones
Interstitial NephritisNSAIDs
Methicillin
Cholestatic JaundiceMacrolides
Coronary VasospasmCocaine
Sumatriptan
GoutThiazides
Disulfiram-like reactionsChlorpropamide
Metronidazole
Cefoxitin
Cefamandole
Atropine-like reactionsTCAs
CoughACE Inhibitors
Aplastic AnemiaCarbamazepine
Chloramphenicol
Gold compounds
EPSAntipsychotics
Fatal HepatotoxicityHalothane
Valproic acid
Thiazolidinediones
Acetaminophen
Gray Baby SyndromeChloramphenicol
GynecomastiaCimetidine
Spironolactone
Alcohol
Hand Foot Syndrome5-FU
Hemolytic anemia w/ G6PD deficiencyPrimaquine
Dapsone
Sulfa drugs
Nitrofurantoin
Chloramphenicol
Hot FlashesNiacin
Tamoxifen
Postural Hypotensionα-Blockers
MyelosuppressionAlkylating cancer drugs
SLE-like reactionsProcainamide
Hydralazine
Methyldopa
Red Man SyndromeVancomycin
Optic NeuritisEthambutol
OtotoxicityAminoglycosides
Loop diuretics
PancreatitisDidanosine
Adrenal InsufficiencySteroid-withdrawal
ThrombocytopeniaHeparin
Rifampin
Rebound HypertensionClonidine-withdrawal
α-Methyldopa
Severe HTN w/ TyramineMAO inhibitors
AgranulocytosisClozapine
CinchonismQuinidine
Antidotes and Drugs Related To Famous Side Effects

Farrukh Mehmood, Pharm-D, M.Phil, RPh

Dr. Farrukh is a Manager of Quality Operations in a renowned Pharmaceutical Industry of Pakistan.

Leave a Reply